The Tigers and Jags are home, while the Saints hit the road to play the Chiefs in Kansas City.
The home teams went 3-0 last weekend, and 9Picks believes they will do it again this weekend.
No. 22 Ole Miss (3-3) at No. 23 LSU (3-2)
LSU starts a brutal stretch that includes five ranked SEC teams in the next six weeks. First up, the Ole Miss Rebels.
The Rebels come to Tiger Stadium averaging 477 yards of offense per game and just under 40 points. The Tigers defense will be put to the test, but with help from Leonard Fournette and company, LSU will pass its first test.
LSU 31, Ole Miss 24
Arkansas-Pine Bluff (1-5) at Southern (3-2)
Southern is finally back home this weekend. The Jags are averaging 50 points a game in their last three contests, while the Golden Lions are giving up 30 points per contest. This one won't be pretty for Ark-Pine Bluff.
Southern 58, Arkansas-Pine Bluff 20
Saints (2-3) at Chiefs (3-2)
The Chiefs will look to run the ball and run the clock against the Saints defense in hopes of keeping Drew Brees and company off the field. The Saints need to get off to a quick start, making the Chiefs offense uncomfortable and playing catch up. A couple of injuries on the Chiefs defense will help the Saints win their third in a row.
Saints 28, Chiefs 27
No. 6 Texas A&M (6-0) at No. 1 Alabama (7-0)
The Tide is averaging 45 points a game; the Aggies average 40. This one has the makings of a shootout, but Alabama is the best team in the SEC and will once again take over the 4th quarter on the Tide's way to an 8-0 record.
Alabama 41, Texas A&M 30
No. 17 Arkansas (5-2) at No. 21 Auburn (4-2)
Arkansas and Auburn look very even on paper. The Hogs beat Ole Miss last weekend, while the Tigers played a complete game against Miss. State. There's just something about Arkansas, and whatever it is will earn them a victory on the Plains.
Arkansas 21, Auburn 16
No. 2 Ohio State (6-0) at Penn State (4-2)
Ohio State escaped last weekend against Wisconsin in overtime, while the Nittany Lions have won their last two games. The Buckeyes average over 500 yards a game in offense and Penn State gives up almost 400 yards a game. That's not good for the Nittany Lions.
Ohio State 32, Penn State 21
TCU (4-2) at No. 12 West Virginia (5-0)
The Mountaineers are quietly having a great season. TCU struggled to beat Kansas 24-23 last weekend. Enough said, home team improves to 6-0.
West Virginia 34, TCU 26
The Tom Herman Watch:
No. 11 Houston (6-1) at SMU (2-4)
Houston has not looked very good the past two weeks, but the Cougars will bounce back against the Mustangs this weekend.
Houston 42, SMU 20
NC State (4-2) at No. 7 Louisville (5-1)
Can NC State put a crushing overtime loss to Clemson behind them this weekend when they face Lamar Jackson and the Cardinals? No, they cannot.
Louisville 48, NC State 24
LAST WEEK: 9-0, OVERALL RECORD: 43-20
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