Running back Derrius Guice and wide receivers D.J. Chark and Malachi Dupre each scored two touchdowns to give LSU a 45-10 victory over Southern Miss in Tiger Stadium. The Tigers scored five touchdowns in the second half after being tied at 10 going into halftime.
Guice had 162 yards rushing on 16 carries, while Dupre had 100 yards receiving and Chark had 91 yards receiving.
LSU quarterback Danny Etling completed 11 of 18 passes for a season-high 276 yards, including three touchdown passes, as the LSU offense had 459 total yards. The Tigers had just 121 offensive yards in the first half.
For the first time in his career, Guice had back-to-back games with 100-push yards rushing and multiple touchdowns. During the game, he also hit 1,000 yards total in his career.
Chark's 80-yard catch is the longest touchdown reception for LSU since 2014 when Travin Dural scored an 82-yard touchdown against Sam Houston State. Chark's catch also ranks eighth for LSU in catches that are 80 yards or more, dating back to 1965.
Malachi Dupre scored his first touchdown of the season with a 63-yard pass from Etling in the third quarter.
LSU (4-2) will host Ole Miss next on Saturday, Oct. 22. Kickoff is set for 8 p.m. with the game to air on ESPN.
Southern Miss' Smith ran 1 yard for a touchdown. (LSU 0, USM 7 - 6:58 1st Qtr)
LSU's D.J. Chark rushed 19 yards for a touchdown. (LSU 7, USM 7 - 2:22 1st Qtr)
LSU's Colby Delahoussaye kicked a 38-yard field goal. (LSU 10, USM 7 - 14:05 2nd Qtr)
Southern Miss' Shaunfield kicked a 37-yard field goal. (LSU 10, USM 10 - 8:28 2nd Qtr)
LSU's Derrius Guice ran 61 yards for a touchdown. (LSU 17, USM 10 - 13:22 3rd Qtr)
LSU's Guice rushed for a 20-yard touchdown. (LSU 24, USM 10 - 10:50 3rd Qtr)
LSU quarterback Danny Etling threw to D.J. Chark for an 80-yard touchdown. (LSU 31, USM 10 - 4:20 3rd Qtr)
LSU's Etling completed a pass to Malachi Dupre for an 63-yard touchdown. (LSU 38, USM 10 - 1:58 3rd Qtr)
LSU's Dupre caught a 23-yard touchdown pass from Etling. (LSU 45, USM 10 - 5:16 4th Qtr)
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