BATON ROUGE, LA (WAFB) - Running backs Derrius Guice and Darrel Williams exploded in Ed Orgeron's debut as LSU's interim head coach, combining for almost 300 yards and six touchdowns, in the Tigers' 42-7 homecoming victory.
Guice scored all three of LSU's touchdowns in the first half, filling in for Heisman hopeful Leonard Fournette, who did not dress again due to an injury. In total, Guice rushed 163 yards on 17 carries.
Guice is the first Tiger to rush for three or more touchdowns since the Texas Bowl, when Fournette had four touchdowns.
Williams also had a great night, scoring LSU's three touchdowns in the second half and getting his first 100-yard rushing game in his LSU career. He had a total of 130 yards on 21 carries.
It also marked the first time LSU had two players rush for more than 100 yards in same game since the Tigers' 45-24 win over South Carolina in October 2015.
Orgeron led the Tigers out of the tunnel just six days after Les Miles was relieved of his coaching duties.
Just as Orgeron said earlier in the week, the offense opened it up against Missouri. LSU had a total of 634 yards, the most in school history for an SEC game. LSU quarterback Danny Etling accounted for 216 of those yards with the passing game, completing 19 of 30 attempts.
The Tigers were on pace for 700 total yards after getting 357 yards in the first half alone.
The LSU defense was been able to hold Missouri's offense to 265 yards.
Missouri came to town with a 2-2 overall record, winning against Eastern Michigan and Delaware State and losing to West Virginia and Georgia.
Going into Saturday's game, the offensive statistics looked very impressive for Mizzou, but a good bit of the team's yardage had come in wins against the two smaller schools.
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Two players were ejected for targeting during the game. LSU's Xavier Lewis was pulled out of the game in the first quarter and Missouri's Brandon Lee was pulled from the game in the third quarter.
Two more players were ejected from the game in the fourth quarter, following a scuffle at the end of the first half, which resulted in both teams being charged with personal fouls. LSU's Andy Dodd and Missouri's Charles Harris were pulled from the game with less than six minutes after each got a second personal foul.
Davon Godchaux did play in the game after originally being suspended indefinitely following an arrest earlier in the week. A day after his arrest, the district attorney said his office would not be pursuing charges against Godchaux.
LSU (3-2) travels on the road next to face off against Florida on Saturday, Oct. 8 at 11 a.m. The game will be televised on ESPN.
LSU running back Derrius Guice ran 42 yards for a touchdown. (LSU 7, MIZ 0 - 6:46 1st Qtr)
LSU's Guice rushed for a 4-yard touchdown. (LSU 14, MIZ 0 - 8:34 2nd Qtr)
Tigers' Guice ran 37 yards for a touchdown. (LSU 21, MIZ 0 - 4:40 2nd Qtr)
LSU running back Darrel Williams rushed 1 yard for a touchdown. (LSU 28, MIZ 0 - 11:09 3rd Qtr)
LSU's Williams ran for a 2-yard touchdown. (LSU 35, MIZ 0 - 10:00 4th Qtr)
Missouri's Eric Laurent threw a trick play to quarterback Drew Lock for a 21-yard touchdown. (LSU 35, MIZ 7 - 6:11 4th Qtr)
Tigers' Williams rushed 9 yards for a touchdown. (LSU 42, MIZ 7 - 4:32 4th Qtr)