Louisville travels to Clemson for the game of the week, LSU hosts Missouri in the first game without Les Miles on the sideline and the Saints head to San Diego to face the Chargers.
The Southern Jags will take a couple weekends off before hitting the road once more, this time against Jackson State on Saturday, Oct. 15.
Tiger fans will also be interested to watch Tom Herman's Houston Cougars host UCONN on Thursday and Jimbo Fisher's Seminoles host North Carolina on Saturday.
Looking to bounce back after a rough 5-4 week, here's the 9 Picks of the Week:
Missouri (2-2) at LSU (2-2)
Missouri comes to Tiger Stadium with wins against Eastern Michigan and Delaware State. Mizzou is averaging 44.5 points per game, 178 yards on the ground and 391 through the air. LSU plays its first game without Les Miles, and interim head coach Ed Orgeron will lead the Tigers out of the tunnel. One of the big questions is whether or not Leonard Fournette will play or not. It will be a much closer game than many expect, with the Tigers coming out on top, the LSU Tigers that is.
LSU 28, Missouri 23
New Orleans Saints (0-3) at San Diego Chargers (1-2)
The Saints travel to the west coast to face the San Diego Chargers. Drew Brees will face his old team with a defense that is struggling through injuries and inexperience. The Chargers are having their issues on defense as well, giving up 403.7 yards per game. It will be a high-scoring affair, but the Saints won't be able to keep up with the Bolts offense.
Chargers 36, Saints 29
The Tom Herman Watch:
Connecticut (2-2) at No. 6 Houston (4-0) on Thursday
LSU fans may take a few minutes to check out the Houston Cougars on Thursday night to see just how that Tom Herman offense works. Houston is averaging 45 points per game and 497.5 yards of offense per game (274 in the air). The Huskies have wins against Maine and Virginia, but will be no match for Houston.
Houston 41, UCONN 20
The Jimbo Fisher Watch:
North Carolina at No. 12 Florida State
Florida State is giving up a lot of points on defense and North Carolina is scoring a lot of points on offense. Will the distractions of the LSU job and rumors of Fisher being high on the coaching list be a distraction for the Seminoles? Maybe, but they did not let if effect them last year and won't this year as well. There will be a lot points scored and a lot of big plays in this one.
Florida State 38, North Carolina 34
The David Shaw Watch:
No. 7 Stanford (3-0) at No. 10 Washington (4-0) on Friday
The Cardinal have already beat Kansas State, USC and UCLA. The Huskies beat Arizona last weekend in their only test of the year. The atmosphere will be electric in Husky Stadium, but so will Stanford's Christian McCaffery.
Stanford 25, Washington 21
No. 8 Wisconsin (4-0) at No. 4 Michigan (4-0)
It looks like LSU lost to a very good team in week one. The Badgers beat Michigan State 30-6 last weekend and now travel to 'The Big House' to face the Wolverines. Michigan is putting up a lot of points and Wisconsin is holding opponents to under 13 points a game. Will offense or defense prevail in this Big 10 matchup?
Michigan 31, Wisconsin 17
No. 3 Louisville (4-0) at No. 5 Clemson (4-0)
The game of the week! The Cardinals are averaging 64.5 points per game, including a 63-20 dismantling of Florida State. Clemson has had trouble finding the offensive form of last year, but played much better against Georgia Tech. It will be Clemson's Deshaun Watson and Louisville's Lamar Jackson putting on quite the show. Clemson has the home crowd and the experience and will win a close one over the Cardinals.
Clemson 38, Louisville 35
No. 23 Florida (3-1) at Vanderbilt (2-2)
The Gators look to get back on track after imploding against Tennessee in Neyland Stadium. Vanderbilt is the perfect opponent to help get back on the winning track, although the Commodores gave the Gators a scare last year in a 9-7 Florida victory.
Florida 19, Vanderbilt 10
No. 11 Tennessee (4-0) at No. 23 Georgia (3-1)
The SEC game of the week. Can Tennessee put the win against Florida behind them and focus on Georgia and can the Bulldogs put the loss to the Rebels behind them and focus on the Vols? Yes to both, which means a win for Rocky Top.
Tennessee 27, Georgia 17
LAST WEEK: 5-4, OVERALL RECORD: 23-13
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