The Panthers led by as many as 15 points and were up 44-31 at the half, but Roman Banks' team scored 46 second half points while going on a 40-21 run in the final 14 minutes to earn the victory.
Southern (16-15, 13-4) also got 17 points from Trelun Banks, while Tre Lynch added 11 and Adrian Rodgers had 10.
The Jags won five of their last six contests and will close out the regular season Saturday at Texas Southern (18-12, 15-2), which has already clinched the SWAC regular season title.
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